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least squares (ordinary) fit model v.6  (GraphPad Software Inc)


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    GraphPad Software Inc least squares (ordinary) fit model v.6
    Least Squares (Ordinary) Fit Model V.6, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/least+squares+(ordinary)+fit+model+v%2E6/least+squares++ordinary++fit+model/pm30403349-134-42-47
    Average 90 stars, based on 1 article reviews
    least squares (ordinary) fit model v.6 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Negative Control:

    Article Title: Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm
    Article Snippet: To determine IC 50 values, the data from each assay (xL3 motility, L4 motility and development) were converted to a percentage with reference to the negative-control (LB* + 0.5% DMSO), and IC 50 values determined using a variable slope four-parameter equation, constraining the top value to 100% and using a least squares (ordinary) fit model (v.6 GraphPad Software).

    Article Title: Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.
    Article Snippet: A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 μM.. Page 2 of 120 ACS Paragon Plus Environment Journal of Medicinal Chemistry 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 3 Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle section and right-hand side (RHS) of the scaffold in order to elucidate the structure-activity relationship (SAR).. Strong SAR allowed for the iterative and directed assembly of a focus set of 64 analogues, from which compound 60 was identified as the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 μM.

    Article Title: Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus
    Article Snippet: Data (MI) from each assay were converted to a percentage compared with the negative control (LB* + 0.5 % solvent), and IC 50 values determined using a variable slope four-parameter equation, constraining the top value to 100 % and using a least squares (ordinary) fit model (v.6 GraphPad Software).

    Solvent:

    Article Title: Screening of the ‘Pathogen Box’ identifies an approved pesticide with major anthelmintic activity against the barber's pole worm
    Article Snippet: To determine IC 50 values, the data from each assay (xL3 motility, L4 motility and development) were converted to a percentage with reference to the negative-control (LB* + 0.5% DMSO), and IC 50 values determined using a variable slope four-parameter equation, constraining the top value to 100% and using a least squares (ordinary) fit model (v.6 GraphPad Software).

    Article Title: Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.
    Article Snippet: A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC50 of 0.29 μM.. Page 2 of 120 ACS Paragon Plus Environment Journal of Medicinal Chemistry 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 3 Medicinal chemistry optimization targeted modifications on the left-hand side (LHS), middle section and right-hand side (RHS) of the scaffold in order to elucidate the structure-activity relationship (SAR).. Strong SAR allowed for the iterative and directed assembly of a focus set of 64 analogues, from which compound 60 was identified as the most potent compound, inhibiting the development of the fourth larval (L4) stage with an IC50 of 0.01 μM.

    Article Title: Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus
    Article Snippet: Data (MI) from each assay were converted to a percentage compared with the negative control (LB* + 0.5 % solvent), and IC 50 values determined using a variable slope four-parameter equation, constraining the top value to 100 % and using a least squares (ordinary) fit model (v.6 GraphPad Software).



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